VANDETANIB IN A CHILD AFFECTED BY NEUROFIBROMATOSIS TYPE 1 AND MEDULLARY THYROID CARCINOMA WITH BOTH NF1 AND HOMOZYGOUS RET PROTO-ONCOGEN GERM-LINE MUTATIONS

Cases of neurofibromatosis type 1 (NF1)-associated medullary thyroid carcinoma (MTC) or C-cell hyperplasia are rarely associated with other endocrine tumors or cases with a multiple endocrine neoplasia type 2.In these patients, mutations were detected in the NF1 gene but Flat Cap no mutations were detected in the RET gene.Although vandetanib has be

Three-year strict experiments with winter rapeseed were conducted in three experimental stations.In the research, Flat Cap winter rape fertilization with elemental sulphur (S) in the doses: 20, 40 and 60 kg S/ha, boron (B) - in the dose of 2 kg B/ha and copper (Cu) - 5 kg Cu/ha were applied.Microelements were introduced separately, in treatments B

Urban development is the result of the interaction between anthropogenic and environmental dimensions.From the perspective of its density, it ranges from high-density populated areas, Sweeper associated with large cities that concentrate the main economic and social thrust of societies, to low-density populated areas (e.g., rural areas, small–med

This article examines portrayals of people with disabilities in three Indonesian major newspapers (the web versions).The portrayals of Summerhill Polo people with disabilities in these newspapers are examined in terms of positive, negative or neutral tones (Clogston 1989, 1992).To determine the tones, the analysis is focussed on the qualitative con